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Careers – Research & Development

Job Title: Scientist/Senior Scientist

Job Code:  DrX025-2017
Department:  BioMAP Division, Research Biology
Reports to:  VP Research Biology
Classification:  Exempt
Location:  South San Francisco, CA

Summary
The successful candidate for the Scientist/Senior Scientist position currently open at the BioMAP division of DiscoverX will be a highly motivated and innovative individual with comprehensive knowledge and expertise in immunology and oncology, including immune-oncology (IO) and autoimmune disease biology. The candidate will be expected to play a pivotal role in leading scientific expertise in our proprietary BioMAP platform technology to support our clients’ drug development programs. The successful candidate will be responsible for the design, analysis and interpretation of compound testing for multiple biopharmaceutical clients. As part of the Research Biology team, the successful candidate will work within a group of talented, motivated and dedicated colleagues as well as collaborate with our clients across the globe to develop successful clinical compounds.

Essential Functions

  • Lead experimental design, analysis and interpretation of data on compound testing in human primary cell-based assays modeling inflammation, oncology and autoimmunity.
  • Hands-on experience and expertise in multi-parametric flow cytometry experiments in the areas of inflammation, immune oncology, and autoimmune disease, encompassing technical design of flow cytometric assays, data analysis and reporting, literature reviews and trouble-shooting.
  • Prepare and deliver clear and concise oral and written presentations for senior management and biopharmaceutical clients. Candidate will be expected to draft, interpret and explain complex in vitro data in the context of physiological and clinical biology.
  • Publication of study results and presentation of findings at multi-disciplinary project team meetings and external scientific conferences.
  • Work within cross-functional teams to achieve group and company goals within defined timeframes and resources.
  • Maintain mastery of relevant and changing scientific literature and incorporate current knowledge and technologies into the BioMAP platform to support the predictive value and knowledge to help guide client programs.
  • Perform other duties as assigned.

Required Education/Experience/Competencies
  • Ph.D. in the life sciences, with a minimum of 3 years of postdoctoral experience preferably in the pharmaceutical or biotech industries.
  • Comprehensive knowledge of human primary cell based assay and cell culture techniques, including proficiency in working with human immune cell types.
  • Strong expertise in primary cell culture, immune cell biology, flow cytometry, biochemical signaling, and analytical skills (FlowJo or related analytical applications).
  • Excellent track record in publishing scientific findings.
  • Ability to independently design, analyze, and interpret cell-based experiments from a variety of techniques including primary cell culture, flow cytometry, immunoassays and immunohistochemistry.
  • Superior presentation and communication skills with the ability to effectively communicate and collaborate in a global environment.
  • Critical thinking, problem-solving, and project management skills are required to manage multiple projects and deadlines.
  • Candidate should be organized, self-motivated and a team player; a consensus builder with a creative mind and well equipped to establish and implement innovative business solutions and concepts.

Preferred Education and Experience
  • Experience with data analysis programs such as Spotfire, Tableau, Prism, and/or familiarity with the R programming language.
  • Previous experience in drug development, particularly in inflammation and IO drug development.


Supervisory Responsibility
This position has no supervisory responsibilities.

Work Environment
Office-based and laboratory-based position. Potential for business travel. This position operates in a BSL1/2 laboatory setting. There is potential for exposure to human tissues and fluids.

Travel
Less than 10% but potential to increse business travel with experience.

Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to talk or hear. This is largely a sedentary role; however, some movement of laboratory studies are required. This would require the ability to conduct experiments, operate laboratory equipment, and bend or stand transfer experiments from one instrument to another.

Position Type/Expected Hours of Work
This is a full-time position, and hours of work and days are regular business hours Monday through Friday. The ability to work a flexible schedule (including evening and weekend work) may be required depending on business needs and job duties.

DiscoverX is an Affirmative Action/Equal Opportunity Employer. We are committed to hiring a diverse and talented workforce.
EOE/AA/M/F/D/V

 


Job Title: Research Associate, Cell-Based Screening and Automation

Job Code:  DrX032-2017
Department:  BioS Profiling Services
Reports to:  Senior Research Associate
Classification:  Non-Exempt (Temporary)
Location:  South San Francisco, CA

Summary
The successful candidate will be working in the Assay Operations team and focus on cell‐based screening assays that are used to identify, profile and develop drug candidates for our pharmaceutical and biotechnology partners. This position will be responsible for running and maintaining the automation used for high throughput screening in human cell-based assays and supporting the biology group in developing novel disease-focused assays.

Essential Functions

  • Running high throughput ELISA and other microwell plate based assays
  • Operation and routine maintenance of the automation systems
  • Data upload, initial analysis, and QA/QC
  • Storage, retrieval, inventory and setup of test substances for cell-based assays
  • Preparation of buffers and reagents needed for all screening assays
  • Upkeep and maintenance of inventory for laboratory reagents and supplies
  • Other duties as assigned

Required Education/Experience/Competencies
  • Minimum of 2 years of industrial or academic laboratory experience
  • B.A./B.S. in biology, molecular biology, biochemistry or a related discipline
  • ELISA or other micro-well plate based assay execution
  • Exceptional organizational and communication skills
  • High attention to detail
  • Must be able to follow SOPs
  • Must be able to work independently
  • Willingness to work in a team environment

Preferred Education and Experience
  • Solid computer skills (Excel, PowerPoint, Word, database, or Prism)
  • Experience with automated liquid handling workstations
  • Basic cell culture experience is a plus
  • Programming experience is a plus


Supervisory Responsibility
This position has no supervisory responsibilities.

Work Environment
Laboratory environment. This role routinely uses standard laboratory equipment. This position operates in a BSL1/2 laboratory setting. There is potential for exposure to human tissues and fluids.

Travel
Less than 10% but potential to increse business travel with experience.

Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to talk or hear. This is largely a sedentary role; however, some movement of laboratory studies are required. This would require the ability to conduct experiments, operate laboratory equipment, and bend or stand transfer experiments from one instrument to another.

Position Type/Expected Hours of Work
This is a full-time position, and hours of work and days are regular business hours Monday through Friday. The ability to work a flexible schedule (including evening and weekend work) may be required depending on business needs and job duties.

DiscoverX is an Affirmative Action/Equal Opportunity Employer. We are committed to hiring a diverse and talented workforce.
EOE/AA/M/F/D/V



NOTE:  Job descriptions are intended to reflect principal job elements essential for the position. They should not be construed to be exhaustive lists of all responsibilities, skills, efforts, or working conditions associated with a job.