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Careers – Research & Development

Job Title: Research Associate, Cell-Based Screening and Automation
Job Code:  DrX014-2017
Department:  BioS Profiling Services
Reports to:  Senior Research Associate
Classification:  Non-Exempt (temporary) conversion to Exempt
Location:  South San Francisco, CA

Summary
The successful candidate will be working in the Assay Operations team and focus on cell‐based screening assays that are used to identify, profile and develop drug candidates for our pharmaceutical and biotechnology partners. This position will be responsible for running and maintaining the automation used for high throughput screening in human cell-based assays and supporting the biology group developing novel disease-focused assays.

Essential Functions
  • Storage, retrieval, inventory and setup of test substances for cell-based assay
  • Must be able to follow SOPs
  • Preparation of buffers and reagents needed for all screening assays
  • Upkeep and maintenance of inventory for laboratory reagents and supplies
  • Running high throughput ELISA and other microwell plate based assays
  • Running and routine maintenance of the automation systems
  • Data upload, initial analysis, and QAQC
  • Other duties as assigned

Required Education/Experience/Competencies
  • Minimum of 1 year of industrial or academic laboratory experience
  • B.A./B.S. in biology, molecular biology, biochemistry or a related discipline
  • ELISA or other microwell plate based assay execution
  • Exceptional organizational and communication skills
  • High attention to detail
  • Willingness to work in a team environment
  • Must be able to work independently

Preferred Education and Experience
  • Solid computer skills (Excel, PowerPoint, Word, database, or Prism)
  • Experience with automated liquid handling workstations
  • Basic cell culture experience is a plus
  • Programming experience is a plus

Supervisory Responsibility
This position has minimal supervisory responsibilities.

Work Environment
Laboratory environment. This role routinely uses standard laboratory equipment. This position operates in a BSL1/2 laboratory setting. There is potential for exposure to human tissues and fluids.

Travel
No travel is expected for this position.

Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to talk or hear. This is largely a sedentary role; however, some movement of laboratory studies are required. This would require the ability to conduct experiments, operate laboratory equipment, and bend or stand to transfer experiments from one instrument to another.

Position Type/Expected Hours of Work
This is a full-time position, and hours of work and days are regular business hours Monday through Friday. The ability to work a flexible schedule (including evening and weekend work) may be required depending on business needs and job duties.

DiscoverX is an Affirmative Action/Equal Opportunity Employer. We are committed to hiring a diverse and talented workforce.
EOE/AA/M/F/D/V
 

Job Title: Scientist, Profiling and Cell Services
Job Code:  DrX015-2017
Department:  EFC Serv - Op Services
Reports to:  Manager, Assay Operations
Classification:  Non-Exempt (temporary) conversion to Exempt
Location:  Fremont, CA

Summary
The successful candidate for the Scientist position will join the Profiling and Screening team to provide support for our high value commercial research services using DiscoverX PathHunter platform and other proprietary technologies. You will be utilizing skills in cell biology, mammalian cell culture, automation and assay development to optimize and validate assays for compound testing and screening.

Essential Functions

  • Optimization of assays to obtain robust performance in screening applications.
  • Validation of cell based assays for profiling and screening projects.
  • Generation of reference data for qualification of assays.
  • Routine testing of customer compounds.
  • Instrument protocol optimization and validation.
  • Daily laboratory notebook entry.
  • Daily database documentation entry.
  • Weekly progress report generation.
  • Monthly Inventory report generation.
  • Participation in and presentation at group laboratory meetings.
  • Perform other duties as required and assigned.

Required Education/Experience/Competencies
  • Bachelors in cell biology or biochemistry plus 3 - 5 years relevant experience.
  • Proven expertise with cell based signaling assays (i.e. GPCR cAMP and Ca2+ second messenger assays).
  • Must be detailed orientated and consistent in experimental approach.
  • Excellent problem solving and interpersonal skills.
  • Must be team-oriented and accustomed to working with other scientists.
  • Demonstrated written and verbal communication skills.
  • Must be comfortable and experienced working in a commercially focused lab environment.

Preferred Education and Experience
  • Experience with lab automation strongly desired (liquid handlers / plate readers, robotics).
  • Experience with database-based analysis software preferred (Activity Base / Spotfire).


Supervisory Responsibility
This position has no supervisory responsibilities.

Work Environment
Laboratory environment. This role routinely uses standard laboratory equipment. This position operates in a BSL1/2 laboratory setting. There is potential for exposure to human tissues and fluids.

Travel
No travel is expected for this position.

Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to talk or hear; stand; walk; use hands to finger, handle or feel; and reach with hands and arms. Some movement of laboratory studies are required. This would require the ability to conduct experiments, operate laboratory equipment, and bend or stand to transfer experiments from one instrument to another. Specific vision abilities required by this job include close vision, distance vision, color vision, peripheral vision, depth perception and ability to adjust focus.

Position Type/Expected Hours of Work
This is a full-time position, and hours of work and days are regular business hours Monday through Friday. The ability to work a flexible schedule (including evening and weekend work) may be required depending on business needs and job duties.

DiscoverX is an Affirmative Action/Equal Opportunity Employer. We are committed to hiring a diverse and talented workforce.
EOE/AA/M/F/D/V

NOTE:  Job descriptions are intended to reflect principal job elements essential for the position. They should not be construed to be exhaustive lists of all responsibilities, skills, efforts, or working conditions associated with a job.