Biological Information | |
---|---|
Background Information: | GRK4 (G protein-coupled receptor kinase 4) is a serine/threonine protein kinase that belongs to the GRK family of kinases. It is primarily expressed in the kidney, where it plays a role in the regulation of blood pressure and sodium homeostasis. GRK4 has been implicated in the development of hypertension and renal disease, as its upregulation or over activation can lead to an increase in blood pressure and sodium reabsorption.
Research has also suggested that GRK4 may play a role in the pathogenesis of several other diseases, including heart failure and obesity. In heart failure, GRK4 has been shown to be upregulated, and may contribute to the development of cardiac dysfunction. In obesity, GRK4 has been implicated in the regulation of adipocyte differentiation and metabolism, and may play a role in the development of insulin resistance. |
Target Class: | Kinase |
Accession Number: | BC117320.1 |
Target Name: | GRK4 |
Target Aliases: | G Protein-Coupled Receptor Kinase 4, GPRK4, GPRK2L, GRK4a |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
GRK4, active
10 µg of active GRK4. C-terminal 6His-tagged, recombinant, human GRK4 full length.
Datasheets
16-057x Datasheet
View Document