Search results: “AR”

Extensive 3′ alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-terminal splice variants. However, their behavioral relevance…

Endogenous mechanisms that orchestrate resolution of acute inflammation are essential in host defense and the return to homeostasis. Resolvin (Rv)D2…

Ligand bias is the ability of compounds to exert differential signal transduction responses on activation of a GPCR. This is…

Presenting a compelling narrative on the pharmacological characterization of the MRGX2 gene. Dr. Brown emphasized the receptor’s importance as a…

Most GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure…

Biological activity of a biotherapeutic is a Critical Quality Attribute (CQA), which needs to be accurately measured by an appropriate…

Cell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or drugs…

Cytokines and their receptors have emerged as major drug targets for inflammatory and autoimmune diseases, allergies, and, more recently, in…

Therapeutic antibodies that can elicit different applications of cell-mediated cytotoxicity, such as Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) and many other effector…

Eurofins DiscoverX, in conjunction with Drug Target Review, sponsored and moderated a Bioassay roundtable discussion webinar with group leaders from…

Glucagon-like peptides, GLP-1 & GLP-2, are well-researched, metabolically significant peptide hormones secreted from the L-cells of the small intestine in…

GPCRs have long been regarded as a low-hanging fruit drug target as they are conveniently located on the cell surface…