Search results: “AR”

Kinase therapeutics includes both monoclonal antibodies (mAbs) and small-molecule inhibitors. DiscoveRx’s PathHunter® protein: protein interaction system uses well-established Enzyme Fragment…

With more than 25% of the world’s population diagnosed with type II diabetes and/or metabolic syndrome, the requirement for cost…

Cell-based assays play an important role in determination of mechanism of action (MOA) for therapeutic antibodies, particularly when evaluating their…

The clinical success of an ever-increasing array of biologics has led to the development of a wide spectrum of immunomodulatory…

Interest in GPCR ligand bias has increased in recent years due to evidence that positive and negative aspects of drug…

Ligand-induced receptor dimerization is an early functional step in receptor activation, representing the most proximal, functional read-out for Interleukin receptors.…

Cell-based bioassays often pose a hurdle during a rapidly moving biologics development program. High standards for assay accuracy, precision, reproducibility…

Cell-based bioassays often pose a hurdle during a rapidly moving biologics development program. High standards for assay accuracy, precision, reproducibility…

Cell-based bioassays often pose a hurdle during a rapidly moving biologics development program. High standards for assay accuracy, precision, reproducibility…

Class I therapeutic antibodies achieve their clinical efficacy not only by binding to their target antigen, but also through Fc…

Kinase targets have been extensively studied in biochemical assays using purified protein fragments for the kinase and the substrate. However,…

Kinase targets have been extensively studied in biochemical assays using purified protein fragments for the kinase and the substrate. However,…