Search results: “Fer”

Information on compound-target engagement obtained from traditional in vitro binding assays differs greatly from that in a physiologically relevant model…

Therapeutic antibodies that can elicit different applications of cell-mediated cytotoxicity, such as Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) and many other effector…

DiscoveRx offers an industry-leading portfolio of over 600 naturally coupled human and ortholog G-protein coupled receptor (GPCR) cell lines designed…

Learn how KILR CD16 effector cells ensure assay reproducibility with higher signal-to-background ratios, without worrying about donor variability. PBMC effector…

Learn how PathHunter signaling reporter assays can be used to evaluate the cellular impact of therapeutics targeting a variety of…

Learn about PathHunter Internalization assays developed to measure translocation of both single-pass and multi-pass receptors (like RTKs, checkpoint receptors and…

Therapeutic regulators require assay data on the impact of Fc effector-mediated function of antibodies during their development as therapeutics. The…

Immune checkpoint receptors play a key role in maintaining antitumor immunity, avert immunopathology, and modulate overall immune homeostasis. However, cancer…

It is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…

PBMC effector cells have inherent donor variability, reducing their consistency and reproducibility in lot release assays. Antibody-Dependent Cell Cytotoxicity (ADCC)…

Here we will describe InCELL Pulse™, which uses DiscoverX’s Enzyme Fragment Complementation (EFC) technology to overcome these limitations of current…

This 30-minute webinar shows you how to make your own cell-based assays to analyze β-arrestin recruitment in any cell type.…