Showing 25–36 of 226 results
The β2-adrenergic receptor (β2AR) has been a model system for understanding regulatory mechanisms of G-protein-coupled receptor (GPCR) actions and plays…
Read Moreβ-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, to initiate signaling on their own, and…
Read MoreSeveral Bevacizumab products are approved for clinical use, with many others in late-stage clinical development worldwide. To aid the harmonization…
Read MoreArrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7-transmembrane receptors (7-TMs), and regulation of…
Read MoreMost therapeutic antibodies have a Fab’ region that binds the antigen, and an Fc region which binds to and activates…
Read MoreThe development of new medicines for treating diseases and new chemical probes for elucidating biological function continues to rely on…
Read MoreTranslocation and Trafficking of Membrane Proteins
Read MoreInformation on compound-target engagement obtained from traditional in vitro binding assays differs greatly from that in a physiologically relevant model…
Read More
