Search results: “Abl”

Learn about the first commercially available SIRPα/CD47 cell-based assay — PathHunter SIRPα Signaling Assay. Find out more about the generation…

Learn about several GPCR assays and which ones to use and why for your research and drug discovery and development…

SHP2 (Src-homology 2 domain-containing phosphatase 2) is a protein tyrosine phosphatase encoded by the human PTPN11 gene.SHP2 is a key…

There are at least three unique features of allosteric ligand-receptor interactions that lead to potentially valuable therapeutic behaviors…

Histone modifications are essential in eukaryotic gene expression and regulation, and are driven by histone writer, eraser, and reader proteins.…

It is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…

With the drug industry’s expanding emphasis on biologics, the need for robust cell-based assays has grown at all stages of…

Immune checkpoint receptors play a key role in maintaining antitumor immunity, avert immunopathology, and modulate overall immune homeostasis. However, cancer…

The complex interactions between tumor cells and the host immune system are only beginning to be understood, however it is…

Cell-based reporter gene assays are a well-established screening modality for developing drugs that target diverse signaling pathways.

Throughout early discovery and particularly for market release, biologic drug candidates require mechanism-of-action (MOA)-based functional, cellular assays as characterisation tools…

The webinar addresses the challenge that much of the GPCR druggable space remains untapped for potential therapeutic targets. To address…