Showing 25–36 of 37 results
The recent appreciation of functional selectivity/ligand bias in GPCR signaling has uncovered new opportunities for therapeutic discovery and continues to…
Read MoreCompounds that bind to allosteric sites offer many benefits over those which interact orthosterically. These include enhanced specificity, ability to…
Read MoreAssays that directly detect compound binding inside cells can be of great utility in translating in vitro data to more…
Read MoreReporter genes are a well-established method used to develop cell-based assays for testing drugs that inhibit or activate targets involved…
Read MoreDiscoveRx has developed a novel application of our established Enzyme Fragment Complementation (EFC) technology that allows us to monitor protein-protein…
Read MoreThere are numerous assays available to measure the activity of enzymes involved in the transfer of a phosphate from ATP…
Read MoreAssays that directly detect compound binding inside cells can be of great utility in translating in vitro data to more…
Read MoreAntibody-dependent cell-mediated cytotoxicity (ADCC) is the mechanism by which many Class I therapeutic antibodies, including rituximab and trastuzumab, achieve clinical…
Read MoreThe screening and functional characterization of novel ligands for G-protein-coupled receptors (GPCRs) remains a key activity in drug discovery process.…
Read MoreAs more is learned about the intricacies of GPCR signaling, the harder it becomes to accurately describe ligand activity using…
Read MoreAs more is learned about the intricacies of GPCR signaling, the harder it becomes to accurately describe ligand activity using…
Read MoreThrough early discovery, screening, characterization, and particularly for market release and commercialization of biologics, drug candidates require physiologically relevant, functional…
Read More
