SPRINTer™ protein turnover biosensor assays overview. Keystone 2021 Poster Presentation. 5 min.
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Learn how PathHunter signaling reporter assays can be used to evaluate the cellular impact of therapeutics targeting a variety of…
Watch NowSHP2 (Src-homology 2 domain-containing phosphatase 2) is a protein tyrosine phosphatase encoded by the human PTPN11 gene.SHP2 is a key…
Read MoreHistone modifications are essential in eukaryotic gene expression and regulation, and are driven by histone writer, eraser, and reader proteins.…
Read MoreIt is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…
Watch NowHere we will describe InCELL Pulse™, which uses DiscoverX’s Enzyme Fragment Complementation (EFC) technology to overcome these limitations of current…
Watch NowKinase inhibitors often potently inhibit several off-target kinases in biochemical assays. Unfortunately, the relevance of these off-target interactions in a…
Watch NowThe webinar focuses on utilizing an InCELL Pulse to characterize small-molecule cellular target engagement. As an example, a case study…
Watch NowDrug efficacy and cellular target engagement studies have traditionally been monitored by evaluation of downstream cellular responses, such as detection…
Read MoreInterleukins are known for their involvement in functioning of both the adaptive and innate immune systems. Interleukins direct immune cells…
Read MoreCystic fibrosis (CF) patients have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that result in reduced…
Read MoreFollowing the recent regulatory approvals of a number of checkpoint inhibitor therapeutics, development of a wide array of immunomodulatory therapeutic…
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