Search results: “Fer”

Opioid receptors are among the most well-known GPCRs that regulate the transmission and perception of pain. Clinical management of severe…

COVID-19 has been declared a global pandemic by WHO. The disease is transmitted when the SARS-CoV-2 virus infects the respiratory…

Interleukins are known for their involvement in functioning of both the adaptive and innate immune systems. Interleukins direct immune cells…

Drug efficacy and cellular target engagement studies have traditionally been monitored by evaluation of downstream cellular responses, such as detection…

Class I therapeutic antibodies achieve their clinical efficacy not only by binding to their target antigen, but also through Fc…

Cell-based bioassays often pose a hurdle during a rapidly moving biologics development program. High standards for assay accuracy, precision, reproducibility…

Cell-based bioassays often pose a hurdle during a rapidly moving biologics development program. High standards for assay accuracy, precision, reproducibility…

Interest in GPCR ligand bias has increased in recent years due to evidence that positive and negative aspects of drug…

Cystic fibrosis (CF) patients have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that result in reduced…

Neutralizing antibodies (NAbs) to biological drugs may cause loss of therapeutic effi cacy and in some cases, loss of endogenous…

Reporter genes are a well-established method used to develop cell-based assays for testing drugs that inhibit targets involved in specific…

The recent appreciation of functional selectivity/ligand bias in GPCR signaling has uncovered new opportunities for therapeutic discovery and continues to…