Owing to their central role in regulating cell signaling pathways, the phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are attractive therapeutic targets in…
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Mast cells play key roles in allergy, anaphylaxis/anaphylactoid reactions, and defense against pathogens/toxins. These cells contain cytoplasmic granules with a…
Read MoreG-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides,…
Read MoreBy suppressing gene transcription through the recruitment of corepressor proteins, B-cell lymphoma 6 (BCL6) protein controls a transcriptional network required…
Read MoreA persistent problem in early small-molecule drug discovery is the frequent lack of rank-order correlation between biochemical potencies derived from…
Read MoreA Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)
Read MoreBromodomain protein 4 (BRD4), a member of the bromodomain and extra-terminal (BET) proteinfamily, acts as a central element in transcriptional…
Read MoreThe non-receptor protein tyrosine phosphatase (PTP) SHP2 is encoded by the proto-oncogene PTPN11 and is a ubiquitously expressed key regulator…
Read MoreWith the hope of discovering effective analgesics with fewer side effects, attention has recently shifted to allosteric modulators of the…
Read Moreβ-Arrestins are ubiquitously expressed in all cell types, and function in the desensitization of G- protein coupled receptors (GPCRs), the…
Read MoreThis article describes the finding of substantial upregulation of mRNA and enzymes of the cytochrome P450 1A family during a…
Read MoreThe glucagon-like peptide-1 receptor (GLP-1R) is an important physiologic regulator of insulin secretion and a major therapeutic target for diabetes…
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