Search results: “IR”

Cell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or drugs…

Class I therapeutic antibodies achieve their clinical efficacy by binding to their target antigen and through Fragment crystallisable region (Fc)…

Whether you’re looking to screen a library of drug candidates for binding to a particular target protein, checking drug cell…

Cellular membrane proteins play important functions in many biological processes. Understanding their roles often requires that these proteins be isolated…

Cytokines and their receptors have emerged as major drug targets for inflammatory and autoimmune diseases, allergies, and, more recently, in…

Learn about PathHunter® checkpoint receptor assays (cell lines and bioassays) for innate and adaptive immunity. Assays discussed include functional cell-based…

Learn about PathHunter pharmacotrafficking assays to identify small molecule compounds that rescue disease relevant mutant membrane proteins like GPCRs, ion…

Learn how InCELL cell-based binding assays can be used to detect compound cell entry and engagement to specific targets including…

Ready-to-Use qualified PathHunter® checkpoint bioassays are fit-forpurpose for potency testing for implementation in downstream development phases and Lot release of…

Histone modifications are essential in eukaryotic gene expression and regulation, and are driven by histone writer, eraser, and reader proteins.…

Immune checkpoint receptors play a key role in maintaining antitumor immunity, avert immunopathology, and modulate overall immune homeostasis. However, cancer…

With the drug industry’s expanding emphasis on biologics, the need for robust cell-based assays has grown at all stages of…