Search results: “AR”

Learn how to easily detect target protein turnover induced by targeted degrader molecules, such as PROTACs (trademark of Arvinas). Discover…

SPRINTer™ protein turnover biosensor assays overview. Keystone 2021 Poster Presentation. 5 min.

Learn how PathHunter signaling reporter assays can be used to evaluate the cellular impact of therapeutics targeting a variety of…

Learn about PathHunter pharmacotrafficking assays to identify small molecule compounds that rescue disease relevant mutant membrane proteins like GPCRs, ion…

SHP2 (Src-homology 2 domain-containing phosphatase 2) is a protein tyrosine phosphatase encoded by the human PTPN11 gene.SHP2 is a key…

Histone modifications are essential in eukaryotic gene expression and regulation, and are driven by histone writer, eraser, and reader proteins.…

It is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…

Inherent donor variability of immune effector cells presents a significant challenge for developing a robust and reproducible ADCC assays for…

With the drug industry’s expanding emphasis on biologics, the need for robust cell-based assays has grown at all stages of…

Here we will describe InCELL Pulse™, which uses DiscoverX’s Enzyme Fragment Complementation (EFC) technology to overcome these limitations of current…

Kinase inhibitors often potently inhibit several off-target kinases in biochemical assays. Unfortunately, the relevance of these off-target interactions in a…

This 30-minute webinar shows you how to make your own cell-based assays to analyze β-arrestin recruitment in any cell type.…