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Scientific Posters ADP Hunter™ Plus: A Rapid, Quantitative HTS Assay for GDP and UDP

There are numerous assays available to measure the activity of enzymes involved in the transfer of a phosphate from ATP…

Scientific Posters A Wide Range of Compound Efficacies Revealed Using PathHunter® Arrestin Assays

DiscoveRx has developed a novel application of our established Enzyme Fragment Complementation (EFC) technology that allows us to monitor protein-protein…

Scientific Posters Driving Robust and Reproducible ADCC and T Cell Redirection with Single Donor KILR® CD16 Effector Cells

Success of ADCC assays is highly dependent on the quality of effector cells used. However, human primary cells (such as…

Presentations [PEGS 2021] Accelerating Development of Therapeutic Interventions for COVID-19

Gaurav Agrawal, Ph.D. Scientific Development Manager Abstract Millions of deaths worldwide have been attributed to COVID-19, caused by the SARS-CoV-2…

Videos Accelerating Immuno-Oncology Drug Discovery with MOA-Reflective, Functional Cell-Based Assays

Listen to the US PEGS 2023 conference talk by Venkatesh Chari, Ph.D. on MOA-reflective, functional cell-based assays (cell lines and…

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Presentations [Immuno-Oncology Summit 2021] Accelerating Immunotherapy Drug Development with Simple Cell-Based Assays for Immune Checkpoint Receptors

Jennifer Lin-Jones, Ph.D. Senior Group Leader, Assay Development

Scientific Posters A High Sensitivity Assay for Kinetic Analysis of Kinases and ATPases Based on Measurement of ADP Accumulation

DiscoveRx has developed a unique assay technology based on an enzyme-coupled detection system that measures ADP accumulation which has been…

Scientific Posters A novel dye-free cytotoxicity assay to selectively measure target cell death in ADCC, CDC CAR-T or T-cell activation assays

Antibody-dependent cell-mediated cytotoxicity (ADCC) is the mechanism by which many Class I therapeutic antibodies, including rituximab and trastuzumab, achieve clinical…

Presentations [Cytokines Summit 2022] Enabling Cytokine Therapeutic Development with Qualified, Functional Cell-Based Assays

Gaurav Agrawal, Ph.D.Scientific Development Manager Discover how cell-based assays and translational services accelerate cytokine-based immunotherapeutic development from early discovery to…

Application Notes Uncover Novel G-Protein or Arrestin-Biased Ligands Using a Suite of GPCR Signaling Cell-Based Assays: A Study of Biased Agonism on Opioid Receptors

As more is learned about the intricacies of GPCR signaling, the harder it becomes to accurately describe ligand activity using…

Application Notes Quantify GPCR Endocytosis and Recycling with PathHunter® GPCR Internalization Assays – Analyzing Therapeutics for Opioid and Cholecystokinin Receptors

Here we show how PathHunter GPCR Internalization assays can be used to differentiate between strongly internalizing and weakly internalizing agonist…

Application Notes Implementing MOA-Reflective ADCC Assays using Ready-to-Use KILR Target and Effector Cells from Screening to Lot Release

The development of antibody-based therapeutics to target the killing of tumor cells has revolutionized the space of immuno-oncology and the…

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