Search results: “Tec”

The clinical success of an ever-increasing array of biologics has led to the development of a wide spectrum of immunomodulatory…

Kinase therapeutics includes both monoclonal antibodies (mAbs) and small-molecule inhibitors. DiscoveRx’s PathHunter® protein: protein interaction system uses well-established Enzyme Fragment…

Orphan GPCRs continue to represent a target class with immense potential for the discovery of novel therapeutic compounds. In spite…

DiscoveRx previously introduced a protein-protein interaction system using enzyme fragment complementation that provides a robust, HTS friendly format for monitoring…

Cystic fibrosis (CF) patients have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that result in reduced…

With more than 25% of the world’s population diagnosed with type II diabetes and/or metabolic syndrome, the requirement for cost…

Both multi- and single-pass membrane receptors constitutively exhibit complicated and dynamic membrane receptor trafficking as well as internalization induced by…

DiscoveRx® has pioneered a novel enzyme complementation system to monitor cellular events such as protein translocation, protein interactions, and degradation…

The cAMP detection technologies are widely used in high throughput screening (HTS) for measuring a functional response of a GPCR…

Reporter genes are a well-established method used to develop cell-based assays for testing drugs that inhibit or activate targets involved…

Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many…

Assays that directly detect compound binding inside cells can be of great utility in translating in vitro data to more…