Search results: “AR”

The screening and functional characterization of novel ligands for G-Protein Coupled Receptors (GPCR) remains a key focus in drug discovery.…

The webinar focuses on utilizing an InCELL Pulse to characterize small-molecule cellular target engagement. As an example, a case study…

Cell-based reporter gene assays are a well-established screening modality for developing drugs that target diverse signaling pathways.

A quantitative and robust bioassay that is reflective of the MOA of the drug is a critical component of any…

GPCRs are privileged drug targets. Approximately 100 receptors still escape from the drug discovery process as they are orphans, without…

Bioassays are critical components of the quality control system for characterizing biologics. This roundtable involves an interactive panel discussion with…

The webinar addresses the challenge that much of the GPCR druggable space remains untapped for potential therapeutic targets. To address…

A common feature of 7TM receptors is that upon activation, the receptors are bound by cellular Arrestin proteins. DiscoveRx has…

Drug efficacy and cellular target engagement studies have traditionally been monitored by evaluation of downstream cellular responses, such as detection…

DiscoveRx has developed a panel of over 120 characterized GPCR cell lines that monitor receptor activity using interaction with human…

Biologics represents one of the fastest growing classes of biopharmaceutical molecules today. One of the major bottlenecks in the development…

Monoclonal antibodies (MAbs) represent one of the fastest growing classes of biotherapeutic molecules today. While many technologies exist for generating…