Search results: “Abl”

Neutralizing antibodies (NAbs) to biological drugs may cause loss of therapeutic effi cacy and in some cases, loss of endogenous…

The cAMP detection technologies are widely used in high throughput screening (HTS) for measuring a functional response of a GPCR…

Both multi- and single-pass membrane receptors constitutively exhibit complicated and dynamic membrane receptor trafficking as well as internalization induced by…

Reporter genes are a well-established method used to develop cell-based assays for testing drugs that inhibit or activate targets involved…

Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many…

It is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…

Ligand-induced receptor dimerization is the first functional step in receptor activation, representing the most proximal, functional read-out for receptor activation.…

DiscoveRx has developed a novel application of our established Enzyme Fragment Complementation (EFC) technology that allows us to monitor protein-protein…

There are numerous assays available to measure the activity of enzymes involved in the transfer of a phosphate from ATP…

Regulatory authorities define biosimilars as drugs that are “highly similar” to or “interchangeable” with an approved biologic. The lack of…

Kinase targets have been extensively studied in biochemical assays using purified protein fragments for the kinase and the substrate. However,…

Ligand-induced receptor dimerization is an early functional step in receptor activation, representing the most proximal, functional read-out for Interleukin receptors.…