Showing 61–72 of 81 results
It is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…
Read MoreDiscoveRx® has pioneered a novel enzyme complementation system to monitor cellular events such as protein translocation, protein interactions, and degradation…
Read MoreReporter genes are a well-established method used to develop cell-based assays for testing drugs that inhibit targets involved in specific…
Read MoreLigand-induced receptor dimerization is an early functional step in receptor activation, representing the most proximal, functional read-out for Interleukin receptors.…
Read MoreDiscoveRx has developed a novel application of our established Enzyme Fragment Complementation (EFC) technology that allows us to monitor protein-protein…
Read MoreThere are numerous assays available to measure the activity of enzymes involved in the transfer of a phosphate from ATP…
Read MoreGPCR activation results in G-protein dependent events such as second messenger signaling, as well as initiation of a host of…
Read MoreKinase targets have been extensively studied in biochemical assays using purified protein fragments for the kinase and the substrate. However,…
Read MoreOne of the major bottlenecks in the development of biosimilars is the need for good bioassays to create potency, stability…
Read MoreChimeric antigen receptor (CAR)-T cells, which are engineered to recognize target cell surface antigens expressed on tumor cells, have shown…
Read MoreLigand-induced receptor dimerization is an early functional step in receptor activation, representing the most proximal, functional readout for Interleukin receptors.…
Read MoreAntibody-dependent cell-mediated cytotoxicity (ADCC) is the mechanism by which many Class I therapeutic antibodies, including rituximab and trastuzumab, achieve clinical…
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