Interleukins are known for their involvement in functioning of both the adaptive and innate immune systems. Interleukins direct immune cells…
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Orphan GPCRs continue to represent a target class with immense potential for the discovery of novel therapeutic compounds. In spite…
Read MoreDiscoveRx previously introduced a protein-protein interaction system using enzyme fragment complementation that provides a robust, HTS friendly format for monitoring…
Read MoreCystic fibrosis (CF) patients have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that result in reduced…
Read MoreOne of the major bottlenecks in the development of biosimilars is the need for good bioassays to create potency, stability…
Read MoreFollowing the recent regulatory approvals of a number of checkpoint inhibitor therapeutics, development of a wide array of immunomodulatory therapeutic…
Read MoreAn assay platform that robustly and sensitively quantifies the kinetics of endogenous protein turnover and target engagement is crucial for…
Read MoreDiscoveRx has pioneered a novel enzyme complementation system to monitor cellular events such as protein translocation, protein interactions, and degradation…
Read MoreNeutralizing antibodies (NAbs) to biological drugs may cause loss of therapeutic effi cacy and in some cases, loss of endogenous…
Read MoreThe cAMP detection technologies are widely used in high throughput screening (HTS) for measuring a functional response of a GPCR…
Read MoreAssays that directly detect compound binding inside cells can be of great utility in translating in vitro data to more…
Read MoreIt is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…
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