Ubiquitin-mediated degradation of signaling proteins is a primary means of signal regulation in a wide variety of cellular processes including…
Read MoreSearch results: “IR”
Showing 73–84 of 99 results
Reporter genes are a well-established method used to develop cell-based assays for testing drugs that inhibit or activate targets involved…
Read MoreLigand-induced receptor dimerization is the first functional step in receptor activation, representing the most proximal, functional read-out for receptor activation.…
Read MoreThe recent appreciation of functional selectivity/ligand bias in GPCR signaling has uncovered new opportunities for therapeutic discovery and continues to…
Read MoreMast cells are principal players in IgE-, and more recently, non-IgE-mediated anaphylactoid reactions or pseudo-allergic Adverse Drug Reactions (ADR). A…
Read MoreNeutralizing antibodies (NAbs) to biological drugs may cause loss of therapeutic effi cacy and in some cases, loss of endogenous…
Read MoreThe pattern of intracellular signaling downstream of GPCR activation is now known to be specific to the ligand-receptor pair as…
Read MoreDiscoveRx has developed a panel of over 30 naturally Gq-coupled or dual coupled GPCR/Arrestin cell lines that can be used…
Read MoreDenosumab (Prolia®) is a fully human sequence derived monoclonal antibody used for the treatment of osteoporosis in menopausal women via…
Read MoreThere are numerous assays available to measure the activity of enzymes involved in the transfer of a phosphate from ATP…
Read MoreRegulatory authorities define biosimilars as drugs that are “highly similar” to or “interchangeable” with an approved biologic. The lack of…
Read MoreKinase targets have been extensively studied in biochemical assays using purified protein fragments for the kinase and the substrate. However,…
Read More