| Biological Information | |
|---|---|
| Background Information: | The cAMP Hunter™ FSHR Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. FSH) based activation of FSHR GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type FSHR , a naturally Gs coupled GPCR. Upon activation of FSHR , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. |
| Target Class: | GPCR |
| Family: | Glycoprotein Hormone Receptors |
| Sub Family: | Class A |
| Accession Number: | NM_000145 |
| Target Name: | FSHR |
| Target Aliases: | Follicle stimulating hormone receptor, LGR1, ODG1, FSHR1, FSHRO |
| Target Species: | Human |
| Cell Background: | CHO-K1 |
| Usage | |
| Product Type: | Stable Cell Lines |
| Application: | Drug Discovery & Development |
| Storage Conditions: | Store in vapor phase of liquid nitrogen. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Functional |
| Assay Measures: | cAMP Detection |
| Detection Method: | Chemiluminescence |
| Additional Information | |
| Brand: | cAMP Hunter™ |
cAMP Hunter™ CHO-K1 FSHR Gs Cell Line
The cAMP Hunter™ CHO-K1 FSHR Gs Cell Line measures FSHR (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols
70-233 cAMP Hunter Gs and Gi Cell Lines REV10 User Manual
View DocumentDatasheets
95-0119C2 Datasheet
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