| Biological Information | |
|---|---|
| Background Information: | The cAMP Hunter™ GLP-1 RA Bioassay Kit provides a robust, and highly sensitive functional, cell-based assay to monitor 3’-5’-cyclic adenosine monophosphate (cAMP) production in cells, as a result of ligand mediated activation of GLP-1 receptor. The bioassay kit contains all the materials needed for a complete assay, including cells, detection reagents, cell plating reagent, positive control agonist, and assay plates. The ready-to-use cryopreserved cells have been manufactured to ensure assay reproducibility and faster implementation from characterization to QC lot-release. This bioassay has been optimized for a 96-well format. Note that control agonist for stimulating the cells, recombinant human Exendin-4, may not be included in the kit, and may be purchased separately. |
| Target Class: | GPCR |
| Family: | Glucagon |
| Sub Family: | Class B |
| Target Name: | GLP1R |
| Target Aliases: | "Glucagon-like peptide receptor 1, GLP-1, GLP-1-R, GLP-1R, GLP1, GLP1R" |
| Target Species: | Human |
| Cell Background: | CHO-K1 |
| Usage | |
| Product Type: | Bioassay Kits |
| Application: | Potency; Commercial Release & Stability |
| Storage Conditions: | Store in vapor phase of liquid nitrogen. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Functional |
| Assay Measures: | cAMP Detection |
| Detection Method: | Chemiluminescence |
| Clinical Relevance | |
| Therapeutic Area: | Metabolic Diseases |
| Additional Information | |
| Brand: | cAMP Hunter™ |
cAMP Hunter™ GLP-1 RA Bioassay Kit
The cAMP Hunter™ GLP-1 RA Bioassay Kit is an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g.Exendin-4) based activation of GLP-1 receptor activity via detection of levels of intracellular cAMP.
User Manuals & Protocols
70-448_cAMP Hunter GLP-1 RA Bioassay Kit User Manual- Rev 0_Final
View DocumentDatasheets
95-0062Y2 Datasheet
View Document