ChemiScreen™ GLP-2 Receptor Stable Cell Line

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The ChemiScreen™ GLP-2 Receptor Stable Cell Line measures GLP2R (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

Catalog #: HTS164C Size: 2 vials
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Biological Information
Background Information:
The ChemiScreen™ GLP-2 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. GLP-2) based activation of GLP2R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GLP2R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of GLP2R , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
GPCR
Family:
Glucagon Receptor Family
Accession Number:
NM_004246
Target Name:
GLP2R
Target Aliases:
Glucagon-like peptide receptor 2, GLP-2 receptor, GLP-2-R, GLP-2R, glucagon-like peptide 2 receptor
Target Species:
Human
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Calcium Flux
Detection Method:
Fluorescence
Clinical Relevance
Therapeutic Area:
Metabolic Diseases
Additional Information
Brand:
ChemiSCREEN™

User Manuals & Protocols

70-427 ChemiSCREEN and ChemiBRITE Cell Lines User Manual REV1

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Datasheets

HTS164C Datasheet

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