ChemiScreen™ NPBW1 Neuropeptide B/W Receptor Stable Cell Line

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The ChemiScreen™ NPBW1 Neuropeptide B/W Receptor Stable Cell Line measures NPBWR1 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

Catalog #: HTS180C Size: 2 vials
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Biological Information
Background Information:
The ChemiScreen™ NPBW1 Neuropeptide B/W Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. neuropeptide B/W) based activation of NPBWR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NPBWR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NPBWR1 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
GPCR
Family:
Neuropeptide W/ Neuropeptide B Receptors
Accession Number:
NM_005285
Target Name:
NPBWR1
Target Aliases:
Neuropeptides B/W receptor 1, NPBWR1, GPR7, Neuropeptide B & W
Target Species:
Human
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Calcium Flux
Detection Method:
Fluorescence
Additional Information
Brand:
ChemiSCREEN™

User Manuals & Protocols

70-427 ChemiSCREEN and ChemiBRITE Cell Lines User Manual REV1

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Datasheets

HTS180C Datasheet

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