ChemiScreen™ Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line

Awaiting product image

The ChemiScreen™ Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line measures CCR5 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells. Macaque version.

Catalog #: HTS010C Size: 2 vials
Inquire
Biological Information
Background Information:
The ChemiScreen™ Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MIP, RANTES) based activation of CCR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR5 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR5 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the rhesus macaque version of the protein.
Target Class:
GPCR
Family:
Chemokine Receptors
Accession Number:
NM_001042773.2
Target Name:
CCR5 (MIP-1 alpha receptor)
Target Aliases:
Chemokine (C-C motif) receptor 5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Target Species:
Rhesus Macaque
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Calcium Flux
Detection Method:
Fluorescence
Additional Information
Brand:
ChemiSCREEN™

User Manuals & Protocols

70-427 ChemiSCREEN and ChemiBRITE Cell Lines User Manual REV1

View Document

Datasheets

HTS010C Datasheet

View Document