| Biological Information | |
|---|---|
| Background Information: | Cortistatin 14 is a neuropeptide expressed in inhibitory neurons of the cerebral cortex. Depresses neuronal activity, and induces slow-wave sleep, likely through antagonism of acetylcholine. It is structurally and functionally similar to somatostatin 14. Competes with somatostatin 14 for binding of somatostatin receptors, for which it is an agonist (IC50s=5, 0.09, 0.3, 0.2, and 0.3nM for receptors sst1-5, respectively). Also thought to be an agonist of MRGPRX2. Provided as 0.5 mg of dry powder alongside reconstitution buffer. |
| Target Name: | Cortistatin 14 |
| Usage | |
| Product Type: | Control Ligands & Inhibitors |
| Application: | Drug Discovery & Development |
| Storage Conditions: | Store at ≤-20°C. Please avoid multiple freeze/thaw cycles. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Additional Information | |
| Brand: | DiscoverX |
Cortistatin 14, Human
Cortistatin 14, Human is an agonist for SSTR1-5 and MRGPRX2. This product is provided as 0.5 mg of dry powder alongside reconstitution buffer.
Datasheets
92-1076 Datasheet
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