| Biological Information | |
|---|---|
| Background Information: | EGFR (Epidermal Growth Factor Receptor), also known as ErbB1 or HER1, is a transmembrane receptor protein that belongs to the family of receptor tyrosine kinases. It is involved in a variety of cellular processes, including cell growth, proliferation, differentiation, and survival.
EGFR is activated by binding to specific ligands, such as epidermal growth factor (EGF) or transforming growth factor alpha (TGF-alpha), which leads to dimerization of the receptor and autophosphorylation of specific tyrosine residues on the intracellular domain. This activates downstream signaling pathways, such as the MAPK/ERK, PI3K/AKT, and JAK/STAT pathways, which regulate gene expression and other cellular functions. Aberrant activation of EGFR has been implicated in several diseases, including cancer, inflammatory disorders, and neurodegenerative diseases. |
| Target Class: | Kinase |
| Family: | Receptor Typosine Kinase (RTK): Growth Factor Receptor |
| Accession Number: | NM_005228.3; NM_201282.1; NM_201283.1; NM_201284.1 |
| Target Name: | EGFR |
| Target Aliases: | EGFR, ERBB1, ERBB, mENA |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
EGFR (T790M), active
N-terminal GST-tagged recombinant, human EGF receptor amino acids 696end containing the mutation T790M.
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14-725x Datasheet
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