Biological Information | |
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Background Information: | The KILR® SK-MEL-28 Cell Pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint modulators, bispecifics, CAR-T, etc.) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell pool is a heterogeneous population of SK-MEL-28 cells that overexpress a ProLabel-tagged housekeeping gene. Upon effector cells-mediated cell lysis, ProLabel is released to the media, where EA in the detection kit produces an EFC signal proportional to the level of ProLabel released. This allows for calculation of percent lysis of the KILR® cell pool. This stable cell pool is provided as two vials of cryopreserved cells. |
Target Name: | SK-MEL-28 |
Target Species: | Human |
Cell Background: | SK-MEL-28 |
Usage | |
Product Type: | Cell Pool |
Application: | Cytotoxicity |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
Assay Measures: | Cytotoxicity |
Detection Method: | Chemiluminescence |
Clinical Relevance | |
Therapeutic Area: | Oncology/Immuno-Oncology |
Additional Information | |
Brand: | KILR® |
KILR® SK-MEL-28 Cell Pool
The KILR® SK-MEL-28 Cell Pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments via ADCC, CDC, and ADCP
User Manuals & Protocols
70-352 KILR Cytotoxicity Assay-Adherent Target Cell Lines REV2 User Manual
View DocumentDatasheets
97-1017P031
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