| Biological Information | |
|---|---|
| Background Information: | N-terminal GST-tagged, recombinant, human MYO3A, amino acids 1-434. Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). Variants in the MYO3A gene have been found to cause variable hearing impairment onset and severity. |
| Target Class: | Kinase |
| Family: | STE (Ser/thr protein kinase) |
| Sub Family: | Serine/threonine kinase |
| Accession Number: | BC119811.1 |
| Target Name: | MYO3A |
| Target Aliases: | MYO3A, DFNB30, Myosin-IIIa myosin 3A, Q8NEV4 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 12 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Biochemical |
| Clinical Relevance | |
| Therapeutic Area: | Developmental disorders |
MYO3A, active
10 µg of active MYO3A. N-terminal GST-tagged, recombinant, human MYO3A, amino acids 1-434.
Datasheets
14-993_Datasheet
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