Biological Information | |
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Background Information: | The PathHunter® IL7R/IL2RG Dimerization Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-7) induced dimerization of IL7R/IL2RG receptors. This product uses EFC technology. The cell line included overexpresses IL7R target protein fused to PK alongside IL2RG target protein fused to EA. Upon ligand-induced dimerization of IL7R/IL2RG, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. |
Target Class: | Cytokine Receptor |
Family: | IL-2 Receptor Family |
Accession Number: | NM_002185.3 |
Target Name: | IL7R/IL2RG |
Target Aliases: | interleukin 7 receptor, CD127, CDW127, IL-7R-alpha, IL7RA, P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1 |
Target Species: | Human |
Cell Background: | DLD1 |
Usage | |
Product Type: | Bioassay Kits |
Application: | Potency; Commercial Release & Stability |
Kit Components: | |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
Assay Measures: | Dimerization |
Detection Method: | Chemiluminescence |
Clinical Relevance | |
Therapeutic Area: | Inflammation/Allergy |
Additional Information | |
Brand: | PathHunter® |
PathHunter® DLD1 IL7R/IL2RG Bioassay Kit
The PathHunter® IL7R/IL2RG Dimerization Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-7) induced dimerization of IL7R/IL2RG receptors.
User Manuals & Protocols
70-310 PathHunter Dimerization Bioassay Kit REV2 User Manual
View DocumentDatasheets
93-0997Y13x Datasheet
View Document