Biological Information | |
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Background Information: | The PathHunter® mGLP1R (ARR1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. exendin-4) based activation of mGLP1R GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The cells included overexpress PK-tagged mGLP1R and EA-tagged β-Arrestin-1. Activation of mGLP1R stimulates the recruitment of β-Arrestin-1 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. |
Target Class: | GPCR |
Family: | Glucagon Receptor Family |
Coupling: | Gs |
Accession Number: | NM_021332 |
Target Name: | GLP1R |
Target Aliases: | Glucagon-like peptide receptor 1, GLP-1R, GLP1Rc |
Target Species: | Mouse |
Cell Background: | CHO-K1 |
Usage | |
Product Type: | eXpress Assay Kits |
Application: | Drug Discovery & Development |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
β-Arrestin isoform: | β-Arrestin-1 |
Assay Measures: | β-Arrestin Recruitment |
Detection Method: | Chemiluminescence |
Clinical Relevance | |
Therapeutic Area: | Metabolic Diseases |
Additional Information | |
Brand: | PathHunter® |
PathHunter® eXpress mGLP1R CHO-K1 β-Arrestin-1 GPCR Assay
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The PathHunter® eXpress mGLP1R CHO-K1 β-Arrestin-1 GPCR Assay measures mGLP1R (ARR1) (GPCR) activity via recruitment of β-Arrestin-1. eXpress kits contain all assay materials: cells, reagents, and plates. Mouse version.
User Manuals & Protocols
70-255 PathHunter B-Arrestin eXpress GPCR Assay User Manual Rev 5
View DocumentDatasheets
93-0974E2x Datasheet
View Document