PathHunter® HEK 293 AR Nuclear Translocation Cell Line

The PathHunter® HEK 293 AR Nuclear Translocation Cell Line measures AR nuclear hormone receptor activation via nuclear translocation. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0177C1 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® AR Nuclear Translocation cell line is a stable, engineered cell line for use in studying drug candidates affecting NHR activation and nuclear translocation. This cell line enables assessment of ligand (e.g. testosterone, fluorotestosterone) based NHR activation via detection of resulting AR nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged AR NHR and nuclear localized EA. Upon activation of AR, induced nuclear translocation leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Nuclear Protein
Sub Family:	Steroid
Accession Number:	NM_000044
Target Name:	AR
Target Aliases:	androgen receptor, KD, AIS, AR8, TFM, DHTR, SBMA, HYSP1, NR3C4, SMAX1, HUMARAAndrogen receptor
Target Species:	Human
Cell Background:	HEK293

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Short term (24 h): Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Translocation
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®