Biological Information | |
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Background Information: | The PathHunter® IL3RA/CD131 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-3) induced dimerization of IL3RA/CD131 receptors. This product uses EFC technology. The cell line included overexpresses IL3RA target protein fused to PK alongside CD131 target protein fused to EA. Upon ligand-induced dimerization of IL3RA/CD131 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. |
Target Class: | Cytokine Receptor |
Family: | IL-3 Receptor Family |
Accession Number: | NM_002183.2 |
Target Name: | IL3RA/CD131 |
Target Aliases: | Interleukin 3 receptor, Interleukin-3 receptor alpha, CD123, IL-3R-alpha, IL3RY, IL3RX, IL3RY, hIL-3Ra, IL3RA, CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, betaGMR |
Target Species: | Human |
Cell Background: | HEK293 |
Usage | |
Product Type: | Stable Cell Lines |
Application: | Drug Discovery & Development |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
Assay Measures: | Dimerization |
Detection Method: | Chemiluminescence |
Clinical Relevance | |
Therapeutic Area: | Inflammation/Allergy |
Additional Information | |
Brand: | PathHunter® |
PathHunter® HEK 293 IL3RA/CD131 Dimerization Cell Line
The PathHunter® HEK 293 IL3RA/CD131 Dimerization Cell Line measures ligand-induced dimerization of IL3RA/CD131 . This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols
70-303 PathHunter Dimerization Assay REV3 User Manual
View DocumentDatasheets
93-0969C1 Datasheet
View Document