Biological Information | |
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Background Information: | The PathHunter® IL-17A/IL-17F Bioassay Kit (Dimerization) provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-17) induced dimerization of IL-17A/IL-17F receptors. This product uses EFC technology. The cell line included overexpresses IL-17F receptor target protein fused to PK alongside IL17A receptor target protein fused to EA. Upon ligand-induced dimerization of IL-17A/IL-17F receptors, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. |
Target Class: | Cytokine Receptor |
Family: | IL-17 Receptor Family |
Accession Number: | NM_014339 |
Target Name: | IL17RA/IL17RC |
Target Aliases: | IL-17R, IL-17 Receptor, IL17 Receptor, Interleukin 17 receptor A, CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17 |
Target Species: | Human |
Cell Background: | U2OS |
Usage | |
Product Type: | Bioassay Kits |
Application: | Potency; Commercial Release & Stability |
Kit Components: | |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
Assay Measures: | Dimerization |
Detection Method: | Chemiluminescence |
Clinical Relevance | |
Therapeutic Area: | Inflammation/Allergy |
Additional Information | |
Brand: | PathHunter® |
PathHunter® IL-17A/IL-17F Bioassay Kit (Dimerization)
User Manuals & Protocols
70-402_PathHunter IL-17 Bioassay kit (Dimerization) User Manual_Rev1
View DocumentDatasheets
93-0999Y3x Datasheet
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