PathHunter® U2OS EGFR/EGFR Dimerization Cell Line

The PathHunter® U2OS EGFR/EGFR Dimerization Cell Line measures ligand-induced dimerization of EGFR/EGFR . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0989C3 Size: 2 vials

Inquire

Biological Information
Background Information:	The PathHunter® EGFR/EGFR Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. EGF) induced dimerization of EGFR/EGFR receptors. This product uses EFC technology. The cell line included overexpresses EGFR target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of EGFR/EGFR , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Kinase
Family:	Receptor Typosine Kinase (RTK): Growth Factor Receptor
Sub Family:	Protein Tyrosine
Accession Number:	NM_005228.3
Target Name:	EGFR/EGFR
Target Aliases:	Epidermal growth factor receptor, ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®