Biological Information | |
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Background Information: | The PathHunter® EGFR/ErbB3 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. heregulinβ-1) induced dimerization of EGFR/ErbB3 receptors. This product uses EFC technology. The cell line included overexpresses ErbB3 target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of EGFR/ErbB3 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. |
Target Class: | Kinase |
Family: | Receptor Typosine Kinase (RTK): Growth Factor Receptor |
Sub Family: | Protein Tyrosine |
Accession Number: | NM_005228.3 |
Target Name: | EGFR/ErbB3 |
Target Aliases: | Epidermal growth factor receptor, ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA, ErbB-3, HER3, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, FERLK, LCCS2, MDA-BF-1, VSCN1 Gene3: |
Target Species: | Human |
Cell Background: | U2OS |
Usage | |
Product Type: | Stable Cell Lines |
Application: | Drug Discovery & Development |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
Assay Measures: | Dimerization |
Detection Method: | Chemiluminescence |
Additional Information | |
Brand: | PathHunter® |
PathHunter® U2OS EGFR/ErbB3 Dimerization Cell Line
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The PathHunter® U2OS EGFR/ErbB3 Dimerization Cell Line measures ligand-induced dimerization of EGFR/ErbB3 . This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols
70-303 PathHunter Dimerization Assay REV3 User Manual
View DocumentDatasheets
93-1125C3 Datasheet
View Document