PathHunter® U2OS ErbB2/ErbB4 Dimerization Cell Line

The PathHunter® U2OS ErbB2/ErbB4 Dimerization Cell Line measures ligand-induced dimerization of ErbB2/ErbB4 . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0960C3 Size: 2 vials

Inquire

Biological Information
Background Information:	The PathHunter® ErbB2/ErbB4 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. heregulinβ-1) induced dimerization of ErbB2/ErbB4 receptors. This product uses EFC technology. The cell line included overexpresses ErbB2 target protein fused to PK alongside ErbB4 target protein fused to EA. Upon ligand-induced dimerization of ErbB2/ErbB4 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Kinase
Family:	Receptor Typosine Kinase (RTK): Growth Factor Receptor
Sub Family:	Protein Tyrosine
Accession Number:	NM_004448.2
Target Name:	ErbB2/ErbB4
Target Aliases:	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2), HER4, p180erbB4, ALS19
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®