Biological Information | |
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Background Information: | The PathHunter® IL6RA/IL6ST Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-6) induced dimerization of IL6RA/IL6ST receptors. This product uses EFC technology. The cell line included overexpresses IL6ST target protein fused to PK alongside IL6RA target protein fused to EA. Upon ligand-induced dimerization of IL6RA/IL6ST , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. |
Target Class: | Cytokine Receptor |
Family: | IL-6 Receptor Family |
Accession Number: | NM_000565.3 |
Target Name: | IL6RA/IL6ST |
Target Aliases: | interleukin 6 receptor, CD126, IL-6R, IL-6R-alpha, IL-6RA, Il6r, GP130, CD130, CDW130, HIES4, HIES4A, HIES4B, IL-6RB, IMD94, STWS2, sGP130 |
Target Species: | Human |
Cell Background: | U2OS |
Usage | |
Product Type: | Stable Cell Lines |
Application: | Drug Discovery & Development |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
Assay Measures: | Dimerization |
Detection Method: | Chemiluminescence |
Clinical Relevance | |
Therapeutic Area: | Inflammation/Allergy |
Additional Information | |
Brand: | PathHunter® |
PathHunter® U2OS IL6RA/IL6ST Dimerization Cell Line
The PathHunter® U2OS IL6RA/IL6ST Dimerization Cell Line measures ligand-induced dimerization of IL6RA/IL6ST . This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols
70-303 PathHunter Dimerization Assay REV3 User Manual
View DocumentDatasheets
93-1045C3 Datasheet
View Document