Biological Information | |
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Background Information: | The PathHunter® PD-L2 Ligand cell line is a stable, engineered cell line designed for use with PD-1 Checkpoint Signaling Cell Lines. When co-cultured, the PD-L2 expressed in this cell line will induce activity of PD-1 receptors, which may be assayed through SH2 domain protein recruitment. This product is a companion product designed to work with Immunoglobulin Superfamily Checkpoint Assays. The cell line included overexpresses PD-L2 cell surface ligand. When co-cultured with the corresponding Checkpoint Signaling Cell Line, the PD-L2 ligand binds to the checkpoint receptor, inducing receptor activity. This receptor activity leads to recruitment of the relevant SH2 domain protein to the checkpoint receptor inside the receptor cell line and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. |
Target Class: | Checkpoint Receptor |
Family: | IgSF (immune inhibitory Receptor ligand) |
Accession Number: | NM_025239.3 |
Target Name: | PD-L2 |
Target Aliases: | Programmed cell death 1 ligand 2, PDCD1LG2, B7DC, Btdc, PDL2, CD273, PD-L2, PDCD1L2, bA574F11.2 |
Target Species: | Human |
Cell Background: | U2OS |
Usage | |
Product Type: | Stable Cell Lines |
Application: | Drug Discovery & Development |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
Assay Measures: | Signaling |
Detection Method: | Chemiluminescence |
Clinical Relevance | |
Therapeutic Area: | Oncology/Immuno-Oncology |
Additional Information | |
Brand: | PathHunter® |
PathHunter® U2OS PD-L2 Ligand Cell Line
The PathHunter® U2OS PD-L2 Ligand Cell Line works with Checkpoint signaling cell lines to induce SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols
70-394 PathHunter Checkpoint Signaling Assay-IgSF REV3 User Manual
View DocumentDatasheets
93-1076C3
View Document