PathHunter® U2OS PRβ Nuclear Translocation Cell Line

The PathHunter® U2OS PRβ Nuclear Translocation Cell Line measures PRβ nuclear hormone receptor activation via nuclear translocation. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0484C3 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® PRβ Nuclear Translocation cell line is a stable, engineered cell line for use in studying drug candidates affecting NHR activation and nuclear translocation. This cell line enables assessment of ligand (e.g. testosterone, norgestrel) based NHR activation via detection of resulting PRβ nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged PRβ NHR and nuclear localized EA. Upon activation of PRβ, induced nuclear translocation leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Nuclear Protein
Family:	NHR
Accession Number:	NM_000926
Target Name:	PRβ
Target Aliases:	Progesterone receptor β, Progesterone receptor beta
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Translocation
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®