Biological Information | |
---|---|
Background Information: | The PathHunter® TGFBR1A/ACVR2A Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GDF-11) induced dimerization of TGFBR1A/ACVR2A receptors. This product uses EFC technology. The cell line included overexpresses TGFBR1A target protein fused to PK alongside ACVR2A target protein fused to EA. Upon ligand-induced dimerization of TGFBR1A/ACVR2A , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. |
Target Class: | Kinase |
Family: | Ser/Thr Kinase |
Sub Family: | Protein Ser/Thr |
Accession Number: | NM_004612 |
Target Name: | TGFBR1A/ACVR2A |
Target Aliases: | Transforming growth factor, Transforming growth factor beta receptor 1, ALK5, TGFR-1, ESS1, LDS1, MSSE, SKR4, TBRI, ALK-5, LDS1A, LDS2A, TBR-i, activin receptor, ACVRLK4, tbetaR-I, AAT5, ACVR2A, ACTRII, ACVR2 |
Target Species: | Human |
Cell Background: | U2OS |
Usage | |
Product Type: | Stable Cell Lines |
Application: | Drug Discovery & Development |
Storage Conditions: | Store in vapor phase of liquid nitrogen. |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Assay Information | |
Assay Type: | Functional |
Assay Measures: | Dimerization |
Detection Method: | Chemiluminescence |
Additional Information | |
Brand: | PathHunter® |
PathHunter® U2OS TGFBR1A/ACVR2A Dimerization Cell Line
The PathHunter® U2OS TGFBR1A/ACVR2A Dimerization Cell Line measures ligand-induced dimerization of TGFBR1A/ACVR2A . This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols
70-303 PathHunter Dimerization Assay REV3 User Manual
View DocumentDatasheets
93-1012C3
View Document