| Biological Information | |
|---|---|
| Background Information: | N-terminal 6His-tagged, recombinant, human Plk4, amino acids 1-303. Plk4 is a member of the serine/threonine protein kinase family. Plays a central role in centriole replication. Its role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation. |
| Target Class: | Kinase |
| Family: | Other Protein Kinase |
| Sub Family: | Serine/threonine kinase |
| Accession Number: | NM_014264.2 |
| Target Name: | Plk4 |
| Target Aliases: | Plk4, PLK-4, SAK, STK18, Serine/threonine-protein kinase PLK4 Polo-like kinase 4 Serine/threonine-protein kinase 18 Serine/threonine-protein kinase Sak, O00444 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 12 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Biochemical |
| Clinical Relevance | |
| Therapeutic Area: | Oncology/Immuno-Oncology |
Plk4, active
10 µg of active PLK4. N-terminal 6His-tagged, recombinant, human Plk4, amino acids 1-303.
Datasheets
16-026_Datasheet
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