| Biological Information | |
|---|---|
| Background Information: | N-terminal GST-tagged, recombinant, human PRK1, amino acids 498-end. PRK1 is a member of the serine/threonine protein kinase family. Involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Acts as a key coactivator of androgen receptor (AR)-dependent transcription. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. |
| Target Class: | Kinase |
| Family: | AGC (protein kinase A, G, & C) |
| Sub Family: | Serine/threonine kinase |
| Accession Number: | NM_002741.5 |
| Target Name: | PRK1 |
| Target Aliases: | DBK, PKN1, PRK1, MGC46204, PRKCL1, PKN, PAK1, PKN-alpha, Serine/threonine-protein kinase N1 Protease-activated kinase 1 Protein kinase C-like 1 Protein kinase C-like PKN Protein kinase PKN-alpha Protein-kinase C-related kinase 1 Serine-threonine protein kinase N, Q16512 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 12 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Biochemical |
| Clinical Relevance | |
| Therapeutic Area: | Oncology/Immuno-Oncology |
PRK1, active
10 µg of active PRK1. N-terminal GST-tagged, recombinant, human PRK1, amino acids 498-end.
Datasheets
15-029_Datasheet
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