| Biological Information | |
|---|---|
| Background Information: | N-terminal 6His-tagged, recombinant, human PRP4, amino acids 663-end. PRP4 is a member of the serine/threonine protein kinase family. It is a transcription factor involved in pre-mRNA splicing. Shares homology with cyclin-dependent kinases and mitogen-activated protein kinases and is thought to be essential for regulating cell growth and survival of some cancers. Reported to be involved in reversing anti-cancer drug-induced cell death in human cancer cell lines through actin cytoskeleton rearrangement and epithelial-mesenchymal transition (EMT). |
| Target Class: | Kinase |
| Family: | CMGC (CDK, MAPK, GSK, CLK, DYRK, SRPK) |
| Sub Family: | Serine/threonine kinase |
| Accession Number: | NM_176800.1 |
| Target Name: | PRP4 |
| Target Aliases: | dJ1013A10.1, PRPF4B, PRP4K, PRP4H, PRP4, KIAA0536, PR4H, Serine/threonine-protein kinase PRP4 homolog PRP4 kinase PRP4 pre-mRNA-processing factor 4 homolog, O43172 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 12 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Biochemical |
| Clinical Relevance | |
| Therapeutic Area: | Oncology/Immuno-Oncology |
PRP4, active
10 µg of active PRP4. N-terminal 6His-tagged, recombinant, human PRP4, amino acids 663-end.
Datasheets
16-005_Datasheet
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