| Biological Information | |
|---|---|
| Background Information: | Rho-associated, coiled-coil containing protein kinase (ROCK), including the ROCK1 and ROCK2 isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. PKA and the two ROCKs have been reported to have opposite effects on neurite formation. More studies are needed to provide significant insights into the role of ROCK in several pathological processes. ROCK inhibitors have been shown the benefit for treatment of various cancers, inflammation, coronary artery spasms and hypertension.
GenBank NM_005406 |
| Target Class: | Kinase |
| Accession Number: | NM_005406.2 |
| Target Name: | ROKβ/ROCK-I |
| Target Aliases: | ROCK1, P160ROCK, MGC131603, p160ROCK, MGC43611, p160-ROCK |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
ROKbeta/ROCK-I, active
N-terminal 6His-tagged recombinant, human ROCK-I amino acids 17-535; autoactivated by incubating with Mg/ATP and re-dialysed to remove excess ATP.
Datasheets
14-601x Datasheet
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