SPRINTer™ KRAS(G12C) Protein Turnover Biosensor Cell Line (A549)

The SPRINTer™ A549 KRAS(G12C) Protein Turnover Biosensor Cell Line is a stable clonal cell line used for monitoring drug-induced protein turnover of KRAS(G12C).

Catalog #: 91-1009C15 Size: 2 vials

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Biological Information
Background Information:	SPRINTer™ Endogenous Protein Turnover Biosensor Cell Lines are stable clonal cell lines used for monitoring drug-induced protein turnover of a specific endogenous target. Genome engineering or editing techniques, such as CRISPR/Cas9, are used to introduce a small tag into the endogenous locus of interest. This allows for the quantitation of changes in target protein levels when cells are treated with therapeutic agents such as targeted protein degraders.
Target Class:	Signaling Pathway
Accession Number:	NP_004976.2, NP_203524.1, P01116
Target Name:	KRAS
Target Aliases:	Kirsten rat sarcoma viral oncogen homolog, KRAS1, K-Ras4B, KRAS proto-oncogene, GTPase
Target Species:	Human
Cell Background:	A549

Usage
Product Type:	Stable Cell Lines
Application:	Targeted Protein Degradation
Storage Conditions:	Short term (24 h): Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Measures:	Targeted Protein Degradation

Clinical Relevance
Therapeutic Area:	Oncology/Immuno-Oncology

Additional Information
Brand:	SPRINTer™