| Biological Information | |
|---|---|
| Background Information: | Thapsigargin is a naturally occurring, cell-permeable plant sesquiterpene lactone that non-competitively inhibits the sarco/endoplasmic reticulum calcium ATPase (SERCA, IC50 ~2-80nM). Effectively increases intracellular calcium levels upon SERCA inhibition, leading to cell activation, increased histamine release from mast cells, and increased cancer cell proliferation. Acts as an anti-inflammatory and induces autophagy in-vivo. Provided as 1 mg of dry powder. |
| Target Name: | Thapsigargin |
| Usage | |
| Product Type: | Control Ligands & Inhibitors |
| Application: | Drug Discovery & Development |
| Storage Conditions: | Store at ≤-20°C. Please avoid multiple freeze/thaw cycles. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Additional Information | |
| Brand: | DiscoverX |
Thapsigargin
Thapsigargin is an inhibitor of SERCA. This product is provided as 1 mg of dry powder.
Datasheets
92-1148 Datasheet
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