| Biological Information | |
|---|---|
| Background Information: | Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist. Zaprinast was an unsuccessful clinical drug candidate. |
| Target Name: | Zaprinast |
| Usage | |
| Product Type: | Control Ligands & Inhibitors |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 23-25°C Please avoid multiple freeze/thaw cycles. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Additional Information | |
| Brand: | DiscoverX |
Zaprinast
Zaprinast is a synthetic cGMP-specific phosphodiesterase (PDE) inhibitor from which sildenafil (Viagra) was developed. It is selective for PDE5, PDE6, PDE9 and PDE11 (IC50s of 0.76, 0.15, 29, and 12 uM, respectively), and is also a GPR35 agonist.
Datasheets
92-1048_Zaprinast_DS_020124
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