PathHunter® Ranibizumab Bioassay HS Kit

The PathHunter Ranibizumab Bioassay HS Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay asseses ligand (e.g. VEGF-165) based on activation of KDR/KDR Kinase activity via detection of Dimerization. The included cell line overexpresses ProLink-tagged KDR/KDR and EA-tagged . Activation of KDR/KDR stimulates the recruitment of and produces EFC signal.This assay has been optimized and qualified with Lucentis® (not supplied in the bioassay kit). Lucentis® is a registered trademark of Genentech, Inc.. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Catalog No. Size Price Quantity
93-0996Y1-00168 1000 dp (10 x 96-well) $8,259.00
93-0996Y1-00167 200 dp (2 x 96-well) $2,399.00

Please contact Customer Service at customerservicedrx@eurofins.com for European (EUR) or United Kingdom (GBP) pricing or log in to see your account-specific pricing.

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Target/Description
Kinase Insert Domain Receptor
Group
Receptor Tyrosine Kinase
Cell Background
HEK 293
Receptor Species
Human
Accession Number
NM_002253.2
Agonist/Ligand
VEGF-165
Assay Measures
Dimerization
Bioassay Target Name
KDR/KDR
Assay Qualified With
Lucentis®
Drug Trademark Owner
Lucentis® is a registered trademark of Genentech, Inc.
Format
See User Manual for Product Configuration Details. The purpose of the control ligand included in the Bioassay Kit is for verification of assay performance relative to the data shown in the Certificate of Analysis for that kit. This control ligand is not intended for use as a reference standard for validation studies and lot release applications. Typically, a reference medicinal product (RMP) that has been pre-defined by the customer as an internal reference standard is used for those applications. The RMP is not provided with the bioassay kit or supplied by Eurofins DiscoverX.
Storage
Short term (<24 h): Store at -80°C; Long term (>24 h): Store in vapor phase of liquid nitrogen.
Coupling
N/A
  • [User Manual] PathHunter® Ranibizumab Bioassay HS Kit

    PathHunter Ranibizumab Bioassay HS Kit provide a functional, robust, highly sensitive, and easy-to-use cell-based assay to study ranibizumab potency and neutralizing antibodies. The bioassay kits contain all the reagents needed for a complete assay including cells, detection reagents, cell plating reagent, positive control agonist, and assay plates. The pre-validated, frozen cells have been man...

    [User Manual] PathHunter® Ranibizumab Bioassay HS Kit