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Anti-BTLA Antibody [6F4]

Human BTLA (or B and T lymphocyte associated), isan Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motif that is induced during activation of T cells. B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

Catalog No. Size Price Quantity
92-1332 100 µg $610.00

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Description
Anti-BTLA Antibody [6F4]
Compound Type
Antagonist
Storage
-20°C
Source
Mouse Monoclonal to Human BTLA
Signaling assay cells were seeded in a 96-well plate and then pre-incubated with a control antibody, followed by co-incubation with the ligand cell line using the assay conditions described below. Following stimulation, signal was detected using the PathHunter Detection Kit according to the recommended protocol.